What disease did Frank have in The Last of Us? So, here’s how his death in the game and HBO show is different. In the game, we never meet Frank alive, at least, which is another departure. One of the most significant examples we’ve seen in the first three episodes is Bill and Frank-namely, the nature of their relationship which is only hinted at in the games. While there are moments that are, shot for shot, taken from the game, for other parts, the show drastically expands on and shifts parts of the narrative in a really meaningful way. It’s set 20 years after a fungal outbreak has decimated much of humanity. The Last of Us is a pitch-perfect adaptation of the 2013 Naughty Dog video game by the same name. If you watched the latest episode of HBO’s post-apocalyptic drama, viewers were left with at least one unanswered question at its bittersweet conclusion, namely what disease did Frank have in The Last of Us that caused him to want to end his life?

Warning: This article contains spoilers for The Last of Us on HBO.

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